[Facial dystrophic calcinosis cutis secondary to acne].

Actas Dermosifiliogr. 2009;100:615-34 622 squamous cell carcinoma5,6; the incidence is higher in men with long-standing lesions situated on the head, neck, or other areas exposed to sunlight.7 The molecular mechanism of this transformation is not fully understood. A number of theories implicate the proteins involved in regulation of the cell cycle, alterations of which could lead to the appearance of other tumors. Carcinoembryonic antigen,8 growth hormone,9 and proteins p63, BCL2, and BCL6 have also been implicated in the pathogenesis of malignant change.10,11 In addition, the role of HPV in the appearance of squamous cell carcinoma is well known. In our case, HPV type 59 was detected in one of the blocks sent for study. This is a strain with a high oncogenic risk, although the viral load in the samples was very low. In conclusion, rapid growth or transformation of seborrheic keratosis may be a sign of the appearance of a squamous cell carcinoma. In these cases, adequate and complete excision of the lesion is recommended.